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A wide range of conditions—from neurological disorders like stroke, spinal cord injury, and Parkinson's disease to severe musculoskeletal issues, age-related degenerative diseases, cardiopulmonary conditions, and functional limitations following cancer treatment—can necessitate the use of manual or electric wheelchairs at various stages.

From a medical and rehabilitative perspective, sitting in an electric wheelchair all day is generally not recommended; even with a high-end, smart electric wheelchair, the body cannot indefinitely withstand prolonged static sitting.